"It was not so heavy the injury, so it is possible for Thursday but it is also possible against Arsenal," he said.
"[The Midtjylland match] in my opinion is a big game because it's a chance to qualify for the Champions League next season. But we have to win a lot of matches of course, it's easily spoken about but doing it is different.
"But it is possible and then we'll see. I think in March a lot of players are coming back and then we'll have a full selection, and with our full selection we were first in the Premier League."
Injury-hit Keane came on in the 70th minute and promptly sustained another problem, as he suffered his fresh injury.
"It's unbelievable," Van Gaal told BT Sport of Keane's injury. "Also, Cameron Borthwick-Jackson, I changed at half-time, because of injury.
"I changed Juan Mata to give him a rest and also Anthony Martial. Then the sub also gets injured. But it's also the programme, I think."
He added: "Everybody shall say it is against Shrewsbury Town and Manchester United has to win but we have seen very difficult results in the FA Cup, not always the top team is winning. So I think we have done it fantastically.
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